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Glucosamine Sulfate 2KCI
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A Dietary Supplement 500 mg |
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BENEFICIAL EFFECTS: Stimulates the manufacture of substances necessary for proper joint function and stimulates joint repair*
Comparison of Glucosamine Preparations: |
Conforms to USP XXIII disintegration requirements Detailed human studies on glucosamine sulfate show an absorption rate as high as 98 percent.
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| Activity | Glucosamine Sulfate | NAG | Glucosamine Hydrochochoride |
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Active intestinal transport |
Yes | No | Yes |
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Detailed absorption studies |
Yes | No | Yes |
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Detailed clinical studies |
Yes | No | No |
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Contains sulfur molecule |
Yes | No | No |
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Long history of use |
Yes | No | No |
Murray. M.T., Encyclopedia of Nutritional Supplements 1996
STRUCTURE/FUNCTION STATEMENT
As some people age, they lose the ability to manufacture sufficient levels of glucosamine. The results is that cartilage loses the ability to act as a shock absorber. The weight– bearing joints, like knees and hips, as well as the joints of the hands, are those most often affected. In affected joints, there may be a great deal of cartilage destruction followed by hardening and formation of large bone spurs in the joints margins Pain, deformity, and limitation of motion in the joint: results. 1 Glucosamine Sulfate’s beneficial effects are straightforward it stimulates the manufacture of substances necessary for the proper joint function and is responsible for stimulating joint repair. 2
GLUCOSAMINE SULFATE VERSUS CARTILAGE EXTRACTS
If you are trying to restore cartilage and joint structures, it is best to use glucosamine sulfate rather than chondroitin or shark cartilage. This is the case because of the improved absorption and utilization of glucosamine sulfate. The absorption rate for chondrotin sulfate is estimated to be between 0 and 8 percent. 3 In contrast, detailed pharmacokinetic studies indicate that after glucosamine sulfate is absorbed, it is preferentially taken up by cartilage and other joint structures where it stimulates the manufacture of chondroitin sulfate and other mucopolysaccharides
KNEES: The supplement glucosamine can keep your knees more limber and combat osteoarthritis. Researchers in Belgium found that osteoarthritis patients who took 1,500 mg of glucosamine daily had none of the knee-cartilage deterioration that patients taking a placebo suffered. Varicose veins can be erased through a painless, less-than-45-minute procedure called radio-frequency closure. Radio-frequency energy enters the vein wall, causing it to shrink and seal. Cost: $3,000
SIDE EFFECTS:
Glucosamine sulfate has an excellent safety record in animal and human studies and many experts recommend that it be considered as the nutrient of choice for prolonged use in joints function and repair. 4 Side effects are generally limited to light to moderate gastrointestinal symptoms, including stomach upset, heartburn, diarrhea, nausea, and indigestion. Glucosamine sulfate is extremely well tolerated and no allergic reactions have been reported.
1Setnikar,I., et al, Pharmacokinetics of Glucosamine in the Dog and Man, Arzneim Forsch 36 (4), 729-735, 1986
2 Setnikar, I et al, Pharmacokinetics of Glucosamine in Man, Arzeim Forch 43 (10), 1109-1113, 1993
3 Morrison, M., Therapeutic Applications of Chondroitin-4– Sulfate, Appraisal of Biologic Properties, Folia Angiol 25, 225-232, 1977
4 Setnikar, I., et al, Effects of Glucosamine Sulfate Studied in Animal Models, Armeim Forsch 41,542-545, 1991
